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Cat. No.	Product Name	Target	Signaling Pathways
T9998	MIND4-19	Sirtuin	Chromatin/Epigenetic; DNA Damage/DNA Repair
	MIND4-19 是一种具有抗肿瘤活性的 SIRT2 抑制剂。
T8452	Dantrolene	Others	Others
	Dantrolene 是一种肌肉松弛剂，是人红细胞谷胱甘肽还原酶的非竞争性抑制剂，其Ki 和IC50值分别为 111.6 μM 和 52.3 μM。它是兰尼碱受体拮抗剂及Ca2+信号稳定剂。它可用于研究恶性高热、亨廷顿病、肌肉痉挛和其他神经阻滞剂恶性综合征。
T6111	Selisistat EX-527,司来司他,SEN0014196	Sirtuin	Chromatin/Epigenetic; DNA Damage/DNA Repair
	Selisistat (EX-527) 是一种去乙酰化酶 SIRT1 的抑制剂 (IC50=38 nM)，具有有效性和特异性。Selisistat 可以用于神经系统疾病如亨廷顿舞蹈病的研究。
T22595	B2 Linazolamide intermediate B impurity 2,CPNQ,5-[4-(4-Chlorobenzoyl)-1-piperazinyl]-8-nitroquinoline,奥司他韦杂质B(2-叠氮杂合物)	Others; Sirtuin	Chromatin/Epigenetic; DNA Damage/DNA Repair; Others
	B2 (Linazolamide intermediate B impurity 2) 促进亨廷顿病和帕金森病细胞模型中的包涵体形成。
T38605	NCT-504	Others	Others
	NCT-504, a selective allosteric inhibitor of PIP4Kγ, exhibits an IC50 value of 15.8 μM. It holds promise for the investigation of Huntington's disease.
T9159	PBT-1033 PB 1033,PBT1033,PBT-2,PBT 2,PBT2	Others	Others
	PBT-1033 (PBT-2) 是一种潜在的神经保护剂，用于治疗阿尔茨海默病和亨廷顿病。
T23331	SC 51089 SC 51089 free base	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	SC 51089 是一种选择性的前列腺素受体 PGE2 拮抗剂，对前列腺素受体亚型具有选择性，具有抗伤害活性，可改善亨廷顿病 R6/1 小鼠模型中的运动缺陷并挽救记忆力下降。
T62839	Dalzanemdor SAGE-718	NMDAR; iGluR	Membrane transporter/Ion channel; Neuroscience
	Dalzanemdor (SAGE-718) 是 NMDA 受体阳性变构调节剂，可用于研究亨廷顿舞蹈病、阿尔茨海默病和认知功能障碍。
T61859	MK-28	Antiviral; PERK	Apoptosis; Immunology/Inflammation
	MK-28 是一种具有选择性的 PERK 激动剂，可降低亨廷顿病模型的毒性并延长生存期。MK-28 对MK28胃癌细胞有显著的杀伤作用。
T2075	Pyrazolo[1,5-a]pyrimidine 4h	Others	Others
	Pyrazolo[1,5-a]pyrimidine 4h 是一种吗啉衍生物，是腺苷 A2A 受体的选择性拮抗剂。在帕金森病和亨廷顿舞蹈症的动物模型中，它已被证明具有神经保护作用。
T9340	1-phenyl-3,4-dihydroisochinoline 3,4-Dihydro-1-phenylisoquinoline,1-苯基-3,4-二氢异喹啉	Others	Others
	1-phenyl-3,4-dihydroisochinoline (3,4-Dihydro-1-phenylisoquinoline) 是神经递质多巴胺的结构类似物，与中枢神经系统中的多巴胺受体相互作用。它已被研究为治疗帕金森病、阿尔茨海默病和亨廷顿舞蹈症等神经疾病的潜在治疗剂。
T13133	Tetrabenazine Metabolite (-)-β-Dihydrotetrabenazine,(-)-β-HTBZ	Monoamine Transporter	Membrane transporter/Ion channel
	Tetrabenazine Metabolite ((-)-β-HTBZ) 是一种囊泡单胺转运蛋白 2 (VMAT2) 抑制剂，是 Tetrabenazine 的一种活性代谢物。Tetrabenazine Metabolite 对 VMAT2 具有高亲和力，其Ki 为13.4 nM。Tetrabenazine Metabolite 常常被用于研究与亨廷顿氏病和其他多动障碍相关的舞蹈病。
T40652	Meclizine Meclozine	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Meclizine (Meclozine) (Meclozine)具有抗组胺作用，可可逆地抑制组胺与H1受体的相互作用。Meclizine 是哌嗪类H1拮抗剂的一个成员。Meclizine 是一种有效的抗运动病剂。Meclizine 可通过血脑屏障。Meclizine 是小鼠组成型雄烷受体(CAR)的激动剂配体，也是人CAR 的反向激动剂。Meclizine 可用于polyQ 毒性疾病的研究，如亨廷顿病。
T39480	Lexanersen WVE-120102,Lexanersen
	Lexanersen (WVE-120102), an antisense oligonucleotide, is utilized in Huntington's disease research.
T40843	1-(Anilinocarbonyl)proline
	1-(Anilinocarbonyl)proline is a compound utilized for identifying dual-action probes within a cell model of Huntington's disease.
T33895	PBT-1033 hydrochloride PBT 1033,PBT2,PBT 2,PBT-2,PBT1033,PBT-1033
	PBT-1033 hydrochloride is a potential neuroprotective agent for the treatment of Alzheimer's disease and Huntington's disease.
T28363	PF-02545920
	PF-02545920, a PDE10 inhibitor, is used potentially for the treatment of Huntington's Disease.
T69441	NSC66098
	NSC66098 is a novel potent inhibitor of Huntington's disease (HD) pathogenesis via targeting CAG repeats RNA and Poly Q protein.
T71969	Remacemide
	Remacemide is a low-affinity NMDA antagonist with sodium channel blocking properties. It has been studied for the treatment of acute ischemic stroke, epilepsy, Huntington's disease, and Parkinson's disease.
T34662	SMER10 SMER-10,SMER 10
	SMER10 is an enhancer of the clearance of mutant aggregate-prone proteins by autophagy in mammalian cell models of Huntington's and Parkinson's disease, independent of rapamycin.
T79865	Votoplam	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Votoplam作为一种基因剪接调节剂，其应用主要在于抑制亨廷顿病。
T38279	C2-8 C2-8
	C2-8 is an inhibitor of polyglutamine (polyQ) aggregation (IC50s = 25 and 0.05 μM for recombinant HDQ51 and in PC12 cells, respectively). It also inhibits polyQ aggregation in organotypic hippocampal slice cultures isolated from R6/2 transgenic mice and reduces neurodegeneration in a dose-dependent manner in a Drosophila model of Huntington's disease. C2-8 (100 and 200 mg/kg) reduces huntingtin aggregate size, reduces neuronal atrophy, and improves motor performance in a rotarod test in the R6/2...
T26683	AUTEN-67 Autophagy enhancer 67,MTMR14 inhibitor,AUTEN67
	AUTEN-67 is a specific inhibitor of MTMR14 and autophagy enhancer with potent antiaging and neuroprotective effects. AUTEN-67 also delays the onset and decreases the severity of Huntington's disease.
T7352L	Pridopidine hydrochloride ASP2314 HCl,Pridopidine HCl,FR310826,ASP-2314 hydrochloride
	Pridopidine Hydrochloride is a dopaminergic stabilizer that has been shown to improve a variety of neurological and psychiatric disorders, including Huntington's disease. Pridopidine Hydrochloride stabilizes psychomotor activity in a state-dependent way t
T38146	Chloroguanabenz (acetate)
	Chloroguanabenz is an antiprion agent and a derivative of the α2-adrenergic receptor agonist guanabenz . It inhibits prion formation in yeast and mammalian cell-based assays. Chloroguanabenz reduces the levels of both soluble and aggregated forms of the truncated Huntingtin derivative Htt48 in an HEK293T cellular model of Huntington's disease.
T80813	WAY-354574	Sirtuin	Chromatin/Epigenetic; DNA Damage/DNA Repair
	WAY-354574为针对Sirtuin（脱乙酰酶）的活性化合物，适用于亨廷顿病（HD）研究。
T61497	Rho-Kinase-IN-2
	Rho-Kinase-IN-2 (Compound 23) is an orally active and selective inhibitor of Rho Kinase (ROCK), which can penetrate the central nervous system (CNS). It exhibits a high affinity for ROCK2 with an inhibition constant (IC50) of 3 nM. This compound is of potential interest for further investigations in the field of Huntington's disease research [1].
T79038	Tau protein aggregation-IN-1
	Tau protein aggregation-IN-1（化合物 0c）是一种针对Tau protein聚集的抑制剂。该化合物主要应用于研究蛋白质折叠障碍类疾病，包括阿尔茨海默病、痴呆、帕金森病、亨廷顿舞蹈病及基于朊病毒引起的海绵状脑病。
T61991	HTT-D3
	HTT-D3 是有效的，具有口服活性的亨廷顿蛋白 (HTT) 剪接调节剂。 HTT-D3 促进 HTT mRNA 降解和 HTT 水平降低。HTT-D3 减少 p-糖蛋白 (P-gp) 流出，在亨廷顿病中具有研究价值。
T73289	mHTT-IN-1
	mHTT-IN-1 (Example 1) 为针对突变亨廷顿蛋白 (mHTT) 的高效抑制剂，该蛋白具毒性，主导遗传性常染色体显性神经退行性疾病—亨廷顿氏病 (HD) 的发生。mHTT-IN-1 能有效降低 mHTT 水平，其 EC50 值为 0.46 nM。
T83947	HDAC4 CHDI Degrader 11
	HDAC4 CHDI Degrader 11是一种高效且选择性的HDAC4降解剂（PROTAC），其在Jurkat E6-1细胞和Jurkat细胞中的DC50值分别为4 nM和6 nM。该化合物由类IIa HDAC抑制剂三氟甲基噁二唑通过连接体与Von Hippel-Lindau (VHL) 蛋白的配体连接而成。在亨廷顿病小鼠细胞模型中，HDAC4 CHDI Degrader 11能强效地降解HDAC4（DC50= 1nM）。在神经母细胞瘤细胞系中，可与P-糖蛋白抑制剂Elacridar联用以实现更有效的降解。
T74247	TPE-MI
	TPE-MI（Tetraphenylethene maleimide）在与马来酰亚胺与硫醇反应前不具荧光性。在与游离的半胱氨酸硫醇标记时，其荧光被激活，后者多在球形蛋白质的核心，仅在展开时显露。TPE-MI适用于测量细胞中未折叠蛋白质的负荷，并能在亨廷顿病诱导的多能干细胞模型中监测蛋白质平衡失衡，以及在形成可见聚合体之前，监测转染突变亨廷顿外显子1的细胞的状况。此外，TPE-MI用于检测双氢青蒿素处理后疟疾寄生虫的蛋白质损伤。应暗处储存。

化合物

Cat.No: T9998

Target: Sirtuin

Cat.No: T8452

Target: Others

Cat.No: T6111

Synonym: EX-527,司来司他,SEN0014196

Target: Sirtuin

Cat.No: T22595

Synonym: Linazolamide intermediate B impurity 2,CPNQ,5-[4-(4-Chlorobenzoyl)-1-piperazinyl]-8-nitroquinoline,奥司他韦杂质B(2-叠氮杂合物)

Target: Others, Sirtuin

Cat.No: T38605

Target: Others

Cat.No: T9159

Synonym: PB 1033,PBT1033,PBT-2,PBT 2,PBT2

Target: Others

Cat.No: T23331

Synonym: SC 51089 free base

Target: Prostaglandin Receptor

Cat.No: T62839

Synonym: SAGE-718

Target: NMDAR, iGluR

Cat.No: T61859

Target: Antiviral, PERK

Pyrazolo[1,5-a]pyrimidine 4h

Cat.No: T2075

Target: Others

1-phenyl-3,4-dihydroisochinoline

Cat.No: T9340

Synonym: 3,4-Dihydro-1-phenylisoquinoline,1-苯基-3,4-二氢异喹啉

Target: Others

Tetrabenazine Metabolite

Cat.No: T13133

Synonym: (-)-β-Dihydrotetrabenazine,(-)-β-HTBZ

Target: Monoamine Transporter

Cat.No: T40652

Synonym: Meclozine

Target: Histamine Receptor

Cat.No: T39480

Synonym: WVE-120102,Lexanersen

1-(Anilinocarbonyl)proline

Cat.No: T40843

PBT-1033 hydrochloride

Cat.No: T33895

Synonym: PBT 1033,PBT2,PBT 2,PBT-2,PBT1033,PBT-1033

Cat.No: T28363

Cat.No: T69441

Cat.No: T71969

Cat.No: T34662

Synonym: SMER-10,SMER 10

Cat.No: T79865

Target: DNA/RNA Synthesis

Cat.No: T38279

Synonym: C2-8

Cat.No: T26683

Synonym: Autophagy enhancer 67,MTMR14 inhibitor,AUTEN67

Pridopidine hydrochloride

Cat.No: T7352L

Synonym: ASP2314 HCl,Pridopidine HCl,FR310826,ASP-2314 hydrochloride

Chloroguanabenz (acetate)

Cat.No: T38146

Cat.No: T80813

Target: Sirtuin

Rho-Kinase-IN-2

Cat.No: T61497

Tau protein aggregation-IN-1

Cat.No: T79038

Cat.No: T61991

Cat.No: T73289

HDAC4 CHDI Degrader 11

Cat.No: T83947

Cat.No: T74247

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